Jeffrey Sachs Lays Out Possible Lab Origin of Covid

Still, both the overlap in the amino acid sequence and the fact that experts in the furin cleavage site of the ENaC-alpha and insertion of genetic material into bat coronaviruses work at the same university could be coincidental, as Harrison and Sachs acknowledge. Some virologists, though, say that the coincidence strains credulity.

“Could be,” Richard Ebright, a molecular biologist at Rutgers University, wrote in an email to The Intercept when asked about the possibility that these things are both chance occurrences. “But the list of coincidences is getting verrrrrrrrrrry long.”

Ebright, a proponent of investigating the origin of SARS-CoV-2 and of investigating both natural-spillover and research-related-spillover, whom Harrison and Sachs thank “for helpful commentary on the manuscript,” spelled out some of the other Covid coincidences that he considers questionable, including its initial outbreak in a city that, well before 2019, had already been pegged as a biosafety risk. Ebright also noted Wuhan’s 1,000-mile distance from the nearest wild bats that carry the type of SARS-related coronaviruses that caused the pandemic. And he pointed to the particular coding of the amino acids in the furin cleavage site of SARS-CoV2.

“The sequence encoding the FCS of the pandemic virus contained two consecutive CGG arginine codons,” Ebright explained in his email. (A codon, or a combination of three nucleotides, supplies the genetic code for a single amino acid, though most amino acids can be represented by multiple different codons. Each nucleotide is represented by a letter — for RNA, either A, C, U, or G.) “This codon usage is unusual for a natural bat SARS-related coronaviruses (for which fewer than 1 in 30 arginine codons are CGG) but is optimal for humans (for which most arginine codons are CGG codons).”

Still, Ebright said that at first he didn’t see the identical amino acid sequences as particularly suspicious. “I had known for more than a year that there was a perfect match to an eight-amino acid sequence present in human ENaC. What I had not known was that the sequence was known to be a functional furin cleavage site and that it was a sequence extensively studied at UNC,” he said. “The crucial point that the ENaC sequence was a known functional site, not just that there happens to be a match to a protein that happens to be in humans. … That suddenly turned it from what I thought to be largely irrelevant to being a logical and obvious choice to proceed.”